The vaccine is safe and effective for all individuals aged 18 and above. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. 0000007733 00000 n endstream endobj startxref 0 %%EOF 72 0 obj <>>> endobj 95 0 obj <> stream Additional Information If you have questions, visit the website or call the telephone number provided 0000098057 00000 n <]/Prev 553136>> A court in Belgium . Moderna bivalent COVID-19 vaccine. 0000004537 00000 n 54 0 obj Generic name: SARS-CoV-2 vaccine 0000013285 00000 n Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. 0000102371 00000 n <>/Metadata 30 0 R>> This includes any possible side effects not listed in this leaflet. "Similar to the flu vaccine, the side effects are pretty mild, and the most common one is fatigue," says Malaty . The last nine ingredients on the list are called 'excipients.' Store in a refrigerator (2C to 8C). 0000107188 00000 n WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. 0000093171 00000 n 0000107040 00000 n The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. It is a proven, safe and relatively old approach. Well send you a link to a feedback form. To help pregnant women make this assessment, they should be provided with To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Use all vaccine in the vial within 6 hours after first puncture. COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). Previous Name: ChAdOx1 nCoV-19 Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. If you feel unwell after vaccination, do not drive or use machines. /Size 89 /Prev 149222 The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. z(2$bW*; ! It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). None of the ingredients in this vaccine can cause COVID-19. Produced in genetically modified human embryonic kidney (HEK) 293 cells. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety It is your choice to receive the COVISHIELD . Vaccine AstraZeneca and those who received control. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. 0000055209 00000 n These include: y %%EOF What is the evidence for use in older age groups? COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: Vaccine efficacy tended to be higher when the interval between doses was longer. How to store COVID-19 Vaccine AstraZeneca 6. 0000098956 00000 n WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. 346 65 United Kingdom, MedImmune Pharma B.V., Nijmegen hb```b``9 |Abl,=@00M(P~. Epub 2020 Dec 8. A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. . The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 0000012641 00000 n >!V9j5LYHCz. ;BV As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. }wfydUj_mr\]]s=']O_Od>MdD.PHTpo 0000015573 00000 n This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection 0000054470 00000 n AstraZeneca vs. Sinovac side effects. 0000099076 00000 n This will help to protect you against COVID-19 in the future. vaccination series and are at higher risk of severe COVID-19 disease. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). 0000005805 00000 n 0000003715 00000 n "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. /Info 87 0 R Contact your doctor or pharmacist if you have any questions about . 0000008003 00000 n The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. ____________________________________________________________________________________. 0000004240 00000 n 0000003743 00000 n 2. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. endstream endobj 75 0 obj <> stream By reporting side effects you can help provide more information on the safety of this vaccine. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. 0000132021 00000 n Once approved, the drugmaker will work with national governments and international health organizations to monitor vaccine recipients for potential side effects from the vaccine that were not seen in clinical trials (this is called surveillance). The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. endstream endobj 76 0 obj <> stream You have rejected additional cookies. . See the end of section 4 for how to report side effects. Seek immediate medical attention if you develop these symptoms in the days following vaccination. This article has been translated from its original language. Pack sizes (not all pack sizes may be marketed): MedImmune UK Ltd The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. People with a history of severe allergic reaction to any component of the vaccine should not take it. 0000008310 00000 n When autocomplete results are available use up and down arrows to review and enter to select. %PDF-1.6 % syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). 0000100169 00000 n The average age of those who have experienced severe allergic reactions so far is . Efficacy. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . 0000025064 00000 n As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. This includes any possible side effects not listed in this leaflet. The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. Six of the 28 died from their clotting complications. Oxford-AstraZeneca COVID-19 vaccine efficacy. (Centers for Disease Control and Prevention). request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. Lagelandseweg 78 0000006393 00000 n RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. %PDF-1.7 % Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. 548 0 obj <> endobj 779 0 obj <> endobj these events. If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. 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