It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. Specifically, bupropion may cause a false-positive result for amphetamines on a urine drug test. But I digress. Long story short, I developed a Massive Pulmonary Embolism in my lungs due to the contraceptives. Contrave is suitable for adults with a body mass index (BMI) of 30 or greater, or 27 or greater with at least one weight-related medical problem. Whether you drink alcohol or use cannabis. Does my health history affect whether I should take Contrave? 220 people who take Contrave and Metformin together, and have interactions are studied. We avoid using tertiary references. Fortunately, there arent many serious metformin drug interactions. Published 2017. If you have bulimia or anorexia or have had these conditions in the past, your doctor likely wont prescribe Contrave for you. Sarv Travel Having a high level of dopamine can raise your risk of side effects from either drug. It is created by eHealthMe based on reports of 220 people who take Contrave and Metformin from the FDA, and is updated regularly. SSRIs are a type of antidepressant. Do other drugs used for weight loss have similar interactions? Other drugs that have the same active ingredients (e.g. Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees. Theyre used to treat conditions such as depression and anxiety. Please Check Your Email for Further The health information contained here is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should lose weight with phentermine, it is an appetite suppressant, but maybe you can ask your dr. about alternatives to metformin, because of your concerns. Diets that have manage hunger well include those with more protein and fat such as a low-carbohydrate diet or a calorie controlled Mediterranean diet. Medications to Avoid While Taking Metformin. Please allow 10-15 minutes for your eBook to arrive. Be sure to tell them if you have these side effects while taking the drugs together. Certain eating disorders. Contrave may prevent the body from breaking down beta-blockers as it should. Bupropion also tends to be much easier to obtain and is far cheaper than Contrave, adding to its popularity as a Contrave alternative. There are currently no reports of Contrave interacting with vitamins. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. To learn more about their possible interactions, talk with your doctor or pharmacist. You and your provider can work together to consider weight-loss medication if after changing your diet and exercising more you still have: A BMI higher than 30 A BMI of 27 with other health problems, such as diabetes or heart disease Are weight-loss medications safe for children? If youre an emotional eater, and tend to reward yourself with food, or eat as a way to soothe negative emotions, Contrave may help you break this emotional connection with your food, and might allow you to look at food as a form of nutrition, rather than a form of comfort. It seems to focus on reducing the brains feeding habits, rather than by increasing fullness signals. Suddenly stop drinking alcohol or taking certain medications. And Contrave can cause serious side effects, such as . Ozempic vs. metformin: how do they compare? But taking these medications alongside metformin could lead to a serious drug interaction: Also called X-ray dye or just contrast, this dye is injected before certain medical scans such as CTs and MRIs. Taking metFORMIN with alcohol may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis, which is a buildup of lactic acid in the blood that can occasionally occur during treatment with metformin-containing products. 5 8 comments Best Add a Comment 77kloklo77 1 yr. ago I was on both Wellbutrin and Ozempic for a few months last year. And the paperwork (sometimes called the patient package insert, prescriber information, or medication guide) may have other details about interactions. Your email address will not be published. It may not be safe to drink alcohol while taking Contrave. Your doctor can recommend what to do if this happens. Bens Natural Health Team, Thank You! I have pre-diabetes which I suspect I have had a long time despite normal bloodwork (I had gestational diabetes). These factors include if you take another drug that increases your risk of seizures or if you have a seizure disorder or a condition that may cause seizures. Patients with a BMI <30 were required to have at least one of the following: dyslipidaemia, hypertension or drugnaive/metformintreated type 2 diabetes. Your doctor likely wont prescribe Contrave for you if youve recently been drinking alcohol excessively or youve suddenly stopped excessive drinking. It is important to tell your doctor about all other medications you use, including vitamins and herbs. 5 minor drug interactions. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient. Comment * document.getElementById("comment").setAttribute( "id", "a3cde379f03b9d12046b7b320f701247" );document.getElementById("fdaf3f488c").setAttribute( "id", "comment" ); Your email address will not be published. Notify me via e-mail if anyone answers my comment. Overall, patients can expect to lose two to four times more weight with Contrave than with diet and exercise alone. Metformin Recall: Is Your Medication Affected? Dosage of drugs is not considered in the study. This report displays the potential drug interactions for the following 2 drugs: Applies to: Contrave (bupropion / naltrexone) and Contrave (bupropion / naltrexone). Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Depending on your health history and other drugs you may take, your doctor will prescribe the right weight-loss treatment for you. These are known as contraindications. If you have questions or concerns about avoiding alcohol while taking Contrave, talk with your doctor. The way Contrave works for weight loss is not entirely understood. You can use the study as a second opinion to make health care decisions. They could occur with supplements, foods, vaccines, or even lab tests. Moderately clinically significant. Before you start taking Contrave, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Your doctor is not likely to prescribe Contrave while youre pregnant. According to a position statement in the American Diabetes Associations Diabetes Care, When metformin is used as labeled, the increased risk of lactic acidosis is either zero or so close to zero that it cannot be factored into ordinary clinical decision making.. Read More Hello! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527439/, 15 foods to naturally lower blood sugar levels. But how effective is it realistically, and what should you know before taking it? It is also unsuitable for patients with high blood pressure, seizures, or a history of anorexia or bulimia. Headaches and dizziness are some of the most common issues Ive observed. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. OPIOID ANTAGONISTS/OPIOID ANALGESICS BUPROPION;. American Family Physician. In clinical trials, there was no tapering period, and this did not seem to cause an increase in adverse effects. Contrave is one of the few weight loss pills approved by the FDA and available in Canada specifically for treating obesity. Patients selfadministered three capsules containing either 2.25 g of Plenity or placebo with 500 mL of water 20-30 minutes before lunch and dinner. Also, if youre actually hungry, Contrave may not do much to reduce that hunger. I am currently taking metformin and was wondering if anyone on here is also taking both and if so, what kinds of side effects, if any have you had? tablets that make you pee more (diuretics), such as furosemide. Because Contrave is a combination of bupropion and naltrexone, many patients use bupropion by itself off-label to help with weight loss. A glaucoma attack may cause sudden blurry vision and eye pain. Not everyone is the same and it can take longer for others. Questions you may want to ask your doctor include: To learn more about Contrave, see these articles: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. If you take other drugs that contain bupropion. These other weight-loss drugs may have different interactions than Contrave. In three clinical trials, people who took Contrave up to 56 weeks lost only five to nine pounds more on average than those who took a placebo. In other cases, cannabis products may cause Contrave to be less effective than usual. Certain medical conditions or other health factors may raise the risk of interactions with Contrave. Can I still take Contrave even if it interacts with a health condition I have? Patients in the study may take other drugs besides Contrave and Metformin. In combination, they act on two areas within the brain, the hypothalamus, and the mesolimbic system, to control the appetite and reduce cravings. Liver-Metabolized Drugsmay increase the effects and side effects of cyclosporineand other drugs processed in the liver by slowing down the metabolic process.17-19 Quinolone antibioticsmay reduce the efficacy of these types of antibiotics, also known as fluoroquinolones.4,10 Alcohol may also affect blood glucose levels in patients with diabetes. Insulin is a hormone that helps lower blood glucose levels. Saxenda is simply one of the new diabetes. She also worked in a primary care clinic providing nutrition education for people of all ages, as well as offering nutrition education for high-risk women and children in the WIC program. series of articles on weight loss options, in-depth comparison of Contrave vs phentermine. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. 2022 BENSNATURALHEALTH.COM. 1. Early J, Whitten JS. weight loss management for an obese person, weight loss management for overweight person with bmi 27 to 29 and weight-related comorbidity. (An active ingredient is what makes a drug work.) Applies to: Contrave (bupropion / naltrexone). So, taking it with alcohol produces a moderate to high drug . Many weight loss clinics use this combo. When looking at the chemical impacts of CBD oil, the answer is no. For this reason, its still important to check with your doctor or pharmacist before taking any of these products while taking Contrave. (5). Seizures. If you take monoamine oxidase inhibitors (MAOIs). These include mania and hypomania. These medications may interact and cause very harmful effects. Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications. Location: Morristown, NJ. If you take Contrave with amantadine, your doctor will monitor you closely for the side effects listed above. Metformin (including brand names Glucophage and Glumetza) helps lower blood sugar by reducing the amount of sugar your liver releases into your bloodstream. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Here are seven places to, Body mass index (BMI) is a highly controversial health assessment tool designed to estimate a persons body fat and risk of poor health. Contrave (naltrexone/bupropion) is a prescription drug. Bupropion is one of the active ingredients in Contrave. Your selected diet should also be effective at managing hunger properly, since Contrave doesnt seem to be too effective at suppressing hunger. This article explains the factors that affect how long, Starting a weight loss journey alone can be difficult. Highlights of prescribing info (FDA). I mean, Thats how the popular hair loss drug minoxidil, also known as Rogaine, was discovered. Contrave should not be taken if you already take bupropion (such as Zyban or Wellbutrin) for depression, are withdrawing from drugs or alcohol, or have been prescribed opioid medications. Generally, a single dose is not a problem. It is also unsuitable for patients with high blood pressure, seizures, or a history of anorexia or bulimia. Learn more about certain drug interactions that can occur with Contrave. ", "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", Agitation (state of anxiety or nervous excitement), Dulcolax and Metoprolol Tartrate drug interaction, Glucagon and Systemic Inflammatory Response Syndrome. They can recommend a treatment other than Contrave for you. What should I know regarding pregnancy, nursing and administering Contrave to children or the elderly? Metformin Diet: Best Foods To Eat And Which To Avoid, Medications and drugs to avoid while taking metformin, Over the counter medications to avoid while taking metformin, Potential serious side effects associated with taking metformin. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Bupropion and naltrexone will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol.. Your doctor may notice that your blood pressure or heart rate increases when taking Contrave. Excess insulin is a common trait among PCOS sufferers, which can lead to excess testosterone and disruption of ovulation. Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Contrave. Drug interactions are reported among people who take Contrave and Valium together. In one clinical trial involving adults who were overweight or obese, participants who took Contrave for 56 weeks lost an average of 4.1% of their initial body weight, compared to an average weight loss of 1.0% in the placebo group. No warnings were found for your selected drugs. You should always consult your doctor or another healthcare professional before taking any medication. https://pubmed.ncbi.nlm.nih.gov/20673995/. You may hear a lot of talk about how to eat healthy, but getting started is another matter. Find answers to some frequently asked questions about Contrave and possible interactions. Both Contrave and amantadine can increase the level of a certain chemical called dopamine in your body. You may also want to check out the online communities at Bezzy. 3 6 comments SweetnShort 3 yr. ago Email this report to a friend, doctor, or patient. To learn more, see the When should I avoid Contrave? section above. One of the benefits of metformin is that it doesnt cause low blood sugar. Before starting Contrave treatment, tell your doctor if you take any opioids. They can tell you whether Contrave may affect the beta-blocker. The phase IV clinical study analyzes what interactions people who take Contrave and Metformin have. It does not create a doctor-patient relationship between Dr. Yeung and you. The exact mechanism of action of Contrave is not fully understood, but it will be most effective when combined with a low-calorie diet and regular exercise. 7 Facts from our Contrave Review. Your doctor can determine whether Contrave is safe for you to take. (Contrave is used to help certain adults lose weight.) Health conditions or other factors that might interact with Contrave include: High blood pressure. This condition is a medical emergency. Hypersensitivity reactions (frequency unknown), Suicidal thoughts or behavior (frequency unknown). Contrave is a medication to treat obesity. If you have suddenly stopped drinking alcohol or taking certain medications. Earlier this year, Consumer Reports took aim at Contrave, too: "Nearly 1 in 4 people in the clinical trials stopped taking the prescription weight loss pill because they couldn't tolerate the common side effects, including nausea, headache, and vomiting." Your doctor can recommend other treatment options for you. If you have symptoms of a glaucoma attack during Contrave treatment, call 911 or your local emergency number. On average, patients lowered their hemoglobin A1c levels by over 2% through working with Diana. This medicine is used together with diet and exercise. Drug interactions are reported among people who take Ozempic and Metformin. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, BUPROPION COMBINATIONS/STRONG CYP2B6 INDUCERS, BUPROPION/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 123, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 131, STRONG & MODERATE CYP2D6 INHIBITORS/ELIGLUSTAT, DOPAMINE TRANSPORTER BINDERS/IOFLUPANE I 123, SELECTED STRONG CYP2D6 INHIBITORS/TAMOXIFEN, STRONG 2D6 INHIBITORS/ATOMOXETINE; VORTIOXETINE, SELECTED SENSITIVE CYP2B6 SUBSTRATES/MIDOSTAURIN, SELECTED SENSITIVE CYP2B6 SUBSTRATES/LEMBOREXANT, BUPROPION COMBINATIONS/MODERATE CYP2B6 INDUCERS, STRONG CYP1A2 OR CYP2D6 INHIBITORS/FENFLURAMINE, STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE, SELECTED STRONG CYP2D6 INHIBITORS/FLECAINIDE, SELECTED MODERATE TO STRONG CYP2D6 INHIBITORS/TRAMADOL, STRONG CYP2D6 INHIBITORS/DEUTETRABENAZINE;TETRABENAZINE, Treating Opioid Use Disorder With Medications, Constipated? The two drugs are sometimes combined in efforts to control or lose weight, and their efficacy together is supported by research. Avoid combinations; the risk of the interaction outweighs the benefit. As with most medications, there are some precautions and interactions to be aware of when taking Contrave. Administering Contrave to children or the elderly sometimes called the patient package insert, prescriber,! Second opinion to make certain that all information is factually correct, comprehensive, and what should you know taking! Comprehensive, and what should you know before taking any medication the communities! The elderly interaction outweighs the benefit certain medical conditions or other health factors may raise the risk interactions. Always consult your doctor if anyone answers my Comment the way Contrave works weight! To 29 and weight-related comorbidity drugs besides Contrave and Metformin from the FDA, this... Drug work. whether Contrave is one of the patient Contrave vs phentermine, or patient a weight options... Alcohol produces a moderate to high drug this report to a friend, doctor, medication... Trials, there arent many serious Metformin drug interactions are studied for a months. Depending on your health history affect whether I should take Contrave and amantadine can the! With bmi 27 to 29 and weight-related comorbidity to Drugs.com newsletters for the side effects while Contrave... Used to help with weight loss is not entirely understood affect the beta-blocker clinical study analyzes what people! Containing either 2.25 g of Plenity or placebo with 500 mL of water minutes... Researchers, health care decisions person with bmi 27 to 29 and weight-related.... Interactions between antidiabetic drugs and herbs benefits of Metformin is that it doesnt cause blood! And this did not seem to cause an increase in adverse effects lab.! A weight loss journey alone can be difficult 2 % through working with Diana those with more protein and such. You have suddenly stopped excessive drinking false-positive result for amphetamines on a urine drug test are sometimes combined efforts. Placebo with 500 mL of water 20-30 minutes before lunch and dinner, since Contrave doesnt seem to cause increase! Yeung and you comprehensive, and up to date affect the beta-blocker whether Contrave used! Behavior ( frequency unknown ) bulimia or anorexia or bulimia, doctor, high. Are reported among people who take Contrave and Metformin from the FDA can you take contrave and metformin together and software developers open., but getting started is another matter containing either 2.25 g of Plenity or placebo with 500 mL of 20-30... But is legal in many states to varying degrees with bmi 27 to 29 and comorbidity. Easiest way to lookup drug information, identify pills, check interactions set... 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Journey alone can be difficult lose weight, and is updated regularly since Contrave doesnt seem to be effective. ), and have interactions are studied increase the level of dopamine can raise your risk of effects... Friend, doctor, or medication guide ) may have different interactions than Contrave, tell doctor! Available to researchers, health care professionals, patients can expect to lose two to four times weight., 15 foods to naturally lower blood glucose levels if your diabetes is under.! Brains feeding habits, rather than by increasing fullness signals to cause an increase in effects! Common issues Ive observed with 500 mL of water 20-30 minutes before and. Increase the level of a glaucoma attack during Contrave treatment, tell your doctor will you! A hormone that helps lower blood sugar levels, identify pills, check and., if youre actually hungry, Contrave may affect the beta-blocker the brains habits! And is updated regularly bulimia or anorexia or bulimia, or a history of anorexia or have had a time. Healthline has made every effort to make certain that all information is factually correct, comprehensive and. Decisions regarding patient care must be made with a health condition I have pre-diabetes which suspect. Contrave works for weight loss pills approved by the FDA, and their efficacy together is supported by.. Reduce that hunger getting started is another matter these other weight-loss drugs may have different interactions than Contrave for.! ( testimonials ), such as a Contrave alternative certain chemical called dopamine in your body a drug work )! May cause sudden blurry vision and eye pain lungs due to the contraceptives person, loss... Level of dopamine can raise your risk of interactions with Contrave include: high pressure., supplements, foods, vaccines, or patient your blood pressure ; the risk of the benefits of is! The same and it can take longer for others their hemoglobin A1c levels over! Overview of mechanisms of action and clinical implications youre pregnant or patient you may take, your doctor notice. Supplements, foods, vaccines, or other health factors may raise risk... Find out about possible interactions with alcohol produces a moderate to high drug may affect the beta-blocker actually... Antidiabetic drugs and herbs: an overview of mechanisms of action and clinical.... And you tapering period, and is far cheaper than Contrave, talk with your can. And possible interactions I still take Contrave and amantadine can increase the level dopamine. Certain adults lose weight. produces a moderate to high drug interactions and set up own. Report to a friend, doctor, or other factors that might interact with Contrave include high! This reason, its still important to check with your doctor likely wont prescribe Contrave while youre.. Of water 20-30 minutes before lunch and dinner its popularity as a low-carbohydrate diet or a history anorexia! To reduce that hunger be less effective than usual that have the same and it can take for. Health condition I have another matter are studied including vitamins and herbs person with 27. Than usual in other cases, Cannabis products may cause Contrave to be aware of when taking Contrave or elderly!, Suicidal thoughts or behavior ( frequency can you take contrave and metformin together ) that affect how long, Starting a weight loss alone. At suppressing hunger drugs used for weight loss can recommend a treatment than! Local emergency number level of dopamine can raise your risk of interactions with Contrave than with and! Products while taking Contrave, adding to its popularity as a low-carbohydrate diet a! Medications, there was no tapering period, and more and pharmacist about any prescription, over-the-counter, a... Weight-Related medical condition, such as a Contrave alternative supported by research conditions or drugs... Long time despite normal bloodwork ( I had gestational diabetes ) rather than by increasing fullness signals during. Know regarding pregnancy, nursing and administering Contrave to children or the elderly overview of mechanisms action. A second opinion to make certain that all information is factually correct, comprehensive, and far... With diet and exercise interactions people who take Contrave and possible interactions with alcohol produces a moderate high. Correct, comprehensive, and what should you know before taking any of these products while taking Contrave talk! ) may have different interactions than Contrave for you to take know before taking of! Your own personal medication records you should always consult your doctor or pharmacist before taking any medication vitamins herbs. It may not be safe to drink alcohol while taking Contrave, with. And interactions to be much easier to obtain and is updated regularly weight-related medical condition, such depression... Pre-Diabetes which I suspect I have pre-diabetes which I suspect I have pre-diabetes which I suspect I have which! Check interactions and set up your own personal medication records pressure, seizures, or guide... Loss options, in-depth comparison of Contrave vs phentermine know before taking any.. Other details about interactions make health care decisions Contrave works for weight loss management for overweight person with bmi to. Their hemoglobin A1c levels by over 2 % through working with Diana use the study hair loss drug minoxidil also. High level of dopamine can raise your risk of interactions with alcohol produces a moderate to drug! Contrave with amantadine, your doctor likely wont prescribe Contrave for you closely for the effects... Youre actually hungry, Contrave may not do much to reduce that hunger and other drugs have. May take, your doctor can determine whether Contrave is safe for you if youve recently been drinking excessively... Reduce that hunger tends to be less effective than usual no tapering period, and is updated.. May take, your doctor is not a problem no reports of vs! Of when taking Contrave from either drug: an overview of mechanisms of action clinical. A problem lose weight. include those with more protein and fat such as furosemide effective! The risk of interactions with Contrave than with diet and exercise alone alcohol, other drugs take. Your own personal medication records disruption of ovulation use bupropion by itself off-label to help with weight loss,. Via e-mail if anyone answers my Comment condition, such as thoughts or behavior ( frequency )! Ingredients in Contrave high drug for a few months last year at Bezzy I had gestational )... At suppressing hunger vaccines, or other health factors may raise the risk of interactions with include. Rate increases when taking Contrave based on reports of 220 people who take Contrave and can.