Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. Crestor contains the active drug rosuvastatin. Theyll likely have you stop taking Zetia and any statin drug you may be using. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. Medications in this drug class prevent your liver from making new cholesterol. I take pravastatin 80mg with absolutely no problem. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Its a place where people with certain conditions can find support and connect with others. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. They didnt take Zetia with other drugs that also treat high cholesterol. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Taking Zetia with a statin may cause this side effect. Dr. John Szawaluk answered. Here are answers to some frequently asked questions about Zetia. Here are some natural statins that may help keep your cholesterol in a healthy. Statins shouldnt be used during pregnancy. Talk with your doctor about birth control options that may be best for you. This date is typically 1 year from the date they dispensed the medication. If you develop serious side effects while taking Zetia, call your doctor right away. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Zetia may also increase the amount of cholesterol thats stored in your gallbladder. This can increase your risk of side effects from either medication. However, you may still experience muscle problems if you use Zetia alone. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. weakness and fatigue (tiredness) headaches. Risk factors for muscle-related problems. However, be sure to take the dosage your doctor prescribes for you. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. Different interactions can cause different effects. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Zetia may cause joint pain. However, it isnt known how Zetia may affect these risks. Any time youre considering taking a supplement, its important to discuss this with your doctor or pharmacist. Some people witness mild symptoms, some have a big impact on their lives due . The phase IV clinical study analyzes which people take Zetia and have Diarrhea. Brand-name medications usually cost more than generics. Examples of statin drugs include: Learn more about how grapefruit may interact with medications. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. Ask your doctor what other medications are better options for you. Theyll guide you on the safest treatment options for you. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. Learn about side effects, dosage, and more. You can take Zetia with or without food. Also tell them about any vitamins, herbs, and supplements you use. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. You can learn more about how we ensure our content is accurate and current by reading our. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Medications in this drug class prevent your liver from making new cholesterol. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Both Zetia and Crestor come as tablets that are swallowed. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. This is because large meals can cause blood to pool excessively in the abdomen. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. Talk with your doctor to learn more about which medications are right for you. The following information is provided for clinicians and other healthcare professionals. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. The heartbeat increases with a feeling of the heart fluttering. Currently GARD aims to provide the following information for this disease: Population Estimate: This section is currently in development. Talk with your doctor right away if you have fever or chills with your joint pain. Zetia may be used with statin drugs or with fenofibrate when used to treat certain conditions. Less commonly, taking Zetia may lead to serious side effects. A malfunctioning ANS is sometimes called 'dysautonomia'. They are caused by deficiencies in enzymes involved in the synthesis of heme. If you have high cholesterol with hypertension (high blood pressure) or diabetes, youll likely have to take other drugs with Zetia to treat these conditions. This can cause Zetia to be less effective. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. These symptoms can be signs of an infection. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Tell them about all prescription, over-the-counter, and other drugs you take. Talk with your doctor about your health history before you take Zetia. Its called homozygous because the genes that cause this condition are inherited from both parents. Statin drugs may pass into breast milk. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. You should always consult your doctor or another healthcare professional before taking any medication. Before trying something new, its common to look for written reviews about the experiences of others. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. For more information on possible side effects of Zetia, see the Zetia side effects section above. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. Plant sterols are similar to cholesterol. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). In studies, weight changes didnt occur in people who took the drug. Crestor is part of the statin drug class. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. Our website services, content, and products are for informational purposes only. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). Its not known if Zetia is safe to take during pregnancy. You may wonder how Zetia compares with other medications that are prescribed for similar uses. Heres some detail on certain side effects this drug may or may not cause. What causes POTS? diarrhea. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. Read More. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. The generic form of Zetia costs about the same as the generic form of Lipitor. Phase IV trials are used to detect adverse drug . Both drugs are typically taken once each day. (A drug class is a group of medications that work in a similar way.) Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. dark colored urine. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. But over time, heavy alcohol use can damage your liver. Use of the terms male and female in this article refers to sex assigned at birth. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. Many rare diseases have limited information. An increase in levels of liver enzymes doesnt usually cause any symptoms. High cholesterol occurs when you have more cholesterol in your blood than your body needs. (A class of drugs is a group of medications that work in a similar way.) Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. This article provides several useful tips on medication disposal. Zetia is metabolized in the small intestine and liver. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. Theyll work with you to create a treatment plan based on scientific evidence and your unique health history. This section doesnt contain all drugs that may interact with Zetia. Zetia generally costs more than Crestor. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). Its not known if Zetia is safe to take during pregnancy. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. Do not use more Zetia than your doctor recommends. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Total cholesterol is the overall amount of cholesterol found in your blood. If you already have liver problems, taking Zetia may worsen your condition. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. They may also check you for signs of muscle breakdown or kidney damage. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. It's Aimee Esther here! An increase in these liver enzymes while using a statin drug can cause severe liver disease. (Fenofibrate is a drug used to lower your triglyceride levels.). You can also ask your pharmacist for information on how to dispose of your medication. Last medically reviewed on September 18, 2021. 2005-2023 Healthline Media a Red Ventures Company. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. trouble in swallowing. Mild side effects of Zetia when taken with a statin (another kind of cholesterol -lowering drug) may include: infection, such as a respiratory . Zetia is sometimes used with medications in the statin drug class. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. However, side effects are generally mild and go away as the body adjusts to the medication. They can recommend treatments that may help with joint pain, or they may recommend a different treatment option for you. Fenofibrate belongs to the fibrate drug class. You should always consult your doctor or another healthcare professional before taking any medication. The expiration date helps guarantee that the medication is effective during this time. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. However, several medicines can be prescribed off-label when needed. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. Statins are drugs used to lower cholesterol. In addition, you may need to watch out for grapefruit. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. This drug has not been studied in pregnant females.*. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Have your doctor measure your heart rate sitting and standing. In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. Zetia and Crestor have some similar side effects and others that differ. Using Zetia for high cholesterol. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Zetias effect on cardiovascular morbidity and mortality isnt known. You can take Zetia at any time during the day, but try to take your dose around the same time each day. stuffy nose. Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. The list below includes factors to consider. No, clinical studies havent shown Zetia to affect blood pressure. Learn more about the link. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. Once diagnosed, many patients face waiting lists as long as two years to get . Your child can take Zetia with or without food. Zetia is meant to be used as a long-term treatment. It belongs to a class of drugs called cholesterol absorption inhibitors. For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. We avoid using tertiary references. All rights reserved. What causes POTS? Zetia can cause mild or serious side effects. These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . This means you should avoid foods that are high in cholesterol and other types of fat. Zetia and Lipitor have some similar side effects and others that vary. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. If youre concerned about joint pain while using Zetia, talk with your doctor. However, animal studies dont always predict what will happens in humans. They can suggest ways to help relieve this side effect. This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. Zetia and Lipitor are both brand-name drugs. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. For more information, see the How Zetia works section below. 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