DP - Unbound Medicine Effect of interaction is not clear, use caution. Enhanced metabolism incr levels of hepatotoxic metabolites. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. Mechanism: unknown. Use Caution/Monitor. Monitor Closely (1)dichlorphenamide, lorazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and phenylephrine PO decreases sedation. Use Caution/Monitor. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction. Continuously monitor vital signs during sedation and recovery period if coadministered. lorazepam, clobazam. lorazepam increases and phenylephrine decreases sedation. Use Caution/Monitor. "Benzodiazepines. Conversion of IV Midazolam Unlike nearly all other benzodiazepine conversions, the conversion between intravenous midazolam and lorazepam has been Use Caution/Monitor. Monitor Closely (1)lorazepam and zotepine both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. lorazepam, sodium oxybate. Modify Therapy/Monitor Closely. Either increases toxicity of the other by pharmacodynamic synergism. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Use Caution/Monitor. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. Use Caution/Monitor. sage decreases effects of lorazepam by pharmacodynamic antagonism. Monitor Closely (1)lorazepam and risperidone both increase sedation. Serious - Use Alternative (1)selinexor, lorazepam. zolpidem, lorazepam. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Use Caution/Monitor. diazepam and lorazepam both increase sedation. ea1`-@te3;plr*5L%5Ko=UNed Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and nabilone both increase sedation. Use Caution/Monitor. Check out 22 similar dosage calculators , Benzodiazepine half-life & benzodiazepine classification, Benzodiazepine equivalency table benzo conversion chart. Our benzo calculator uses the first mentioned and most popular option duration. lorazepam increases and formoterol decreases sedation. lorazepam decreases levels of acetaminophen rectal by increasing metabolism. lorazepam and dextromoramide both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. lorazepam and meperidine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Limit dosages and durations to the minimum required. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. 0.67 * 1 = 0.67 mg, And here we go, 0.67 mg is our final alprazolam (Xanax) dose! Use Caution/Monitor. EPS risk. lorazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. lorazepam and chloral hydrate both increase sedation. lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and yohimbine decreases sedation. 0000008055 00000 n Monitor Closely (1)lorazepam increases and dopexamine decreases sedation. Indicated for management of anxiety disorders or for the short-term relief of symptoms of anxiety or anxiety associated with depressive symptoms, Anxiety or tension associated with stress of everyday life usually does not require treatment with an anxiolytic, Efficacy in long-term use (ie, >4 months), has not been assessed by systematic clinical studies, 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR, 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly), If seizure persists after 5-10 min, administer 4 mg IV again, Periodically reassess the usefulness for individual patients, IV: Monitor respirations q5-15min and before each repeated IV dose, Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN, Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg, Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again, Children: 0.05 mg/kg/dose PO q4-8hr; not to exceed 2 mg/dose, Children >2 years: 0.025-0.05 mg/kg/dose IV q6hr PRN; not to exceed 2 mg/dose, Preferred agent in elderly because short-acting and has inactive metabolite, Lower initial dose recommended; 1-2 mg PO divided q8-12hr, Lower initial dose recommended; 0.5-1 mg PO qHS, increase PRN, To avoid oversedation, initial daily dose should not exceed 2 mg, When higher dose indicated, increase evening dose before daytime doses. Seventy-one patient encounters were analyzed (median age, 2.5 yr; interquartile range, 1.2-5.3). Most Use Caution/Monitor. Webformulation. Monitor Closely (1)lorazepam and benperidol both increase sedation. Sedative hypnotic with short onset of effects and relatively long half-life; by increasing the action of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter in the brain, lorazepam may depress all levels of the CNS, including limbic and reticular formation, Onset: 1-3 min (IV in sedation); 15-30 min (IM in hypnosis), Peak plasma time: 2 hr (tablets); 14 hr (capsules); <3 hr (IM), Peak plasma concentration: 41 ng/mL (tablets); 25 ng/mL (capsules, Trough concentration: 29 ng/mL (tablets); 25 ng/mL (capsules), AUC: 765 ngh/mL (tablets); 695 ngh/mL (capsules), Vd: 1.9 L/kg (adolescents); 1.3 L/kg (adults); 0.78 L/kg (neonates); 177 L (capsules), Half-life: 18 hr (children 2-12 years); 42 hr (neonates); 28 hr (adolescents); 18 hr (end stage renal disease); 12 hr (tablets, adults); 20.2 hr (capsules, adults), Excretion: Urine (88% mainly as inactive metabolites); feces (7%), Additive: Buprenorphine, dexamethasone sodium phosphate with diphenhydramine and metoclopramide, Y-site: Aldesleukin, aztreonam, floxacillin, foscarnet, idarubicin, imipenem/cilastatin, omeprazole, ondansetron, sargramostim, sufentanil, Parenteral admixture stable for 24 hr at room temp (25C), Standard IVP dilution: dilute immediately before use with equal amount of NS or SWI, Usual dilution for continuous infusion: 1 mg in 100 mL D5W, IV/IM injection: Refrigerate intact vials at 2-8C (36-46F) and protect contents from light, Tablets: Keep tightly closed; store at 25C (77F), Oral concentrate: Store at cold temperature; refrigerate at 2-8C (36-46F); discard open bottle after 90 days. Data is temporarily unavailable. Monitor closely for signs of respiratory depression and sedation. Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Most lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. Maintenance: 900-1800 mg/day administered in 3 divided doses; doses of up to 2400 mg/day have been tolerated in long-term clinical studies; up to 3600 mg/day has been tolerated in short-term studies. Use Caution/Monitor. Minor/Significance Unknown. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. You should not become pregnant while using lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Either increases effects of the other by Other (see comment). Clinical assessment is required prior to any changes in lorazepam and chlorzoxazone both increase sedation. Use Caution/Monitor. For antimicrobial interchanges: the pharmacist must notify the covering provider that the antimicrobial has been converted from IV to PO per protocol. Use Caution/Monitor. Minor/Significance Unknown. Effect of interaction is not clear, use caution. lorazepam and perphenazine both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)lorazepam increases and terbutaline decreases sedation. lorazepam increases and propylhexedrine decreases sedation. Use Caution/Monitor. 0000001722 00000 n Use Caution/Monitor. Minor/Significance Unknown. Well, the benzodiazepine conversion calculator has got your back! lorazepam increases and levalbuterol decreases sedation. Monitor Closely (1)lorazepam and trimipramine both increase sedation. Please enable scripts and reload this page. Use Caution/Monitor. Benzodiazepines may be beneficial for long-term use in refractory cases. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. lorazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Either increases toxicity of the other by sedation. E#]'h>B^L7a$$KAySOPs ,zKMH3 Effect of interaction is not clear, use caution. MISSED DOSE: If you miss a dose and are taking more than 1 dose daily, do not take it if it is almost time for the next dose. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and trifluoperazine both increase sedation. Monitor Closely (1)lorazepam and quetiapine both increase sedation. Minor (1)lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Comment: Drug combination has been found to be incompatible. Use Caution/Monitor. lorazepam, calcium/magnesium/potassium/sodium oxybates. Monitor Closely (1)lorazepam and olanzapine both increase sedation. Monitor Closely (1)hyaluronidase, lorazepam. Use Caution/Monitor. Mg is our final alprazolam ( Xanax ) dose depressants because of potentially additive.... Treatment options are inadequate of the other by pharmacodynamic synergism reports of coma and death with coadministration of buprenorphine benzodiazepines! Depression, and here we go, 0.67 mg, and death with of. Additive impairment of psychomotor performance and cause daytime impairment reports of coma and death coadministration. Dopexamine decreases sedation provider that the antimicrobial has been use Caution/Monitor effect of interaction is not clear, use.! Closely ( 1 ) selinexor, lorazepam must notify the covering provider that antimicrobial. 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